A lot of good comments have already been made, so I don't have much to add, but I will make a few comments.
The number one thing you can do to create a positive environment for your big paw is educate yourself. Once you learn about the health, nutrition, grooming, training, exercise, and socialization needs of your dog, you are much better prepared for a happy and healthy life with them.
Since big paws will grow to be large quickly, it is important to frequently socialize, train, and groom them as puppies. This way, they are more likely to be comfortable and cooperative as they grow.
It is also especially important with a large breed to begin proper nutrition early, with high quality food designed for large breed puppies. Some vetrinarians even recommend feeding adult food to slow growth in order to help reduce the possible effects of hip dysplacia in the future. You might also want to consider supplements for your large breed. The two common types of supplements for large breeds are joint supplements (such as glucosamine/chondroitin/msm), since joint issue such as dysplacia are common in giant breeds, and coat supplements (omega 3 fatty acids most commonly found in fish oil).
In order to make your home a safe environment for any dog, especially a large breed dog, it is important to keep any dangers or toxins out of reach of your dog. With a large breed it is important to remember that they are tall enough to reach most tables and counters, as well as the fact that a wagging tail can accidentally knock things down, so don't keep anything breakable or hazardous near the edge.
Large dogs are prone to hip problems, so it is important to make your home comfortable for them if they have sore joints. Provide soft bedding - prefferably multiple beds so that your dog can be comfortable in any room it spends time in. Also, if you do not have carpet, area rugs or foam/rubber floor mats will give your pet much more traction on slippery floors. Keeping nails and under-paw fur trimmed will also increase traction. Additionally, ramps for your car or front steps will help reduce pain from jumping and climbing.
It is also important to provide dogs with activities to keep them enriched and active. Walk them daily to keep them fit and happy. And remember to give them plenty of toys and chewies to keep them busy in the house - if you entertain them with dog friendly activities they wont see a need to destroy your things.