When Navarre started to get a bit worse (granted his was arthritis) and the Rimadyl and/or Duramax weren't doing as good a job the vet's office manager told me about Synovi G3. I was just giving him glucosamine w/chondrontin and she said that probably didn't have the other necessary ingredients (she was right). It has the MSM, chondrontin, vit, and min necessary for the uptake of the others and Navarre did awesome on it! It took about a week or so to tell a difference. Don't buy it from the vet, look on-line, oddly enough I just found it on Amazon (I googled it to confirm the name). I'm thinking about going ahead and giving it to Daphne since she's a bit older before I see any signs. And I may even start Issabeaux on it too.