What's the ratio of time outside to time inside? Because setters are ALL about their noses, and if she's consistently spent more time inside than outside, that hunting nose of hers is very likely OVERWHELMING her brain when you take her out. Remember, she's been bred to scent and hunt down birds, and those instincts can be very, very strong, even if she's never been hunt trained.
The running is absolutely a breed thing. Irishes are supposed to be big, fancy, wide-ranging hunters, not close-in foot dogs like Clumbers or cockers. She's going to run every time she gets a chance unless you've got her on a lead--that's what she's bred to do, just like a husky or a coonhound. I've heard a lot of people say it's a bad idea to ever trust ANY hunting dog off lead unless you're actually hunting or trialing--even the close hunters.
You need to start spending a lot of time outside in your yard doing your obedience work with her--come, sit, stay, heel, down, etc., so she learns to hear you over her nose.
In fact, you may need to set her up a kennel outside for her to simply be in for a couple of hours a day, to exercise her nose. I know, it sounds weird, but Barney swears that his dogs are calmer and better behaved if he kennels them outside for a 2-3 hours a day. His theory is that their brains work out what it is that they're scenting, and that helps them be more focused the rest of the time--although they will be distracted by a new smell. He has great dogs, so I'd give the kennel a try.