don't know about saints, but i have an akita who is about 140, we got him done at about 6 months old, i think, and he did great. no problems with healing, and he's actually like what... 4 or 5 inches over the standard, and a lot heavier, even though he's not fat by any means. he is a little fluffy though. it didn't stunt his growth or anything at all. our dane is now 8 months and he's still intact. we don't have any problems with him behaviorally (being territorial, marking, etc) and it's not causing any problems, so because he is having trouble gaining weight, we're waiting a little bit because i don't want him to not eat for a few days like some dogs can do after neutering, IMO i think it'd do diesel more harm than good right now.